Evidence based medications and doses for Guideline directed Medical Therapy in the treatment of heart failure.
| Agent | Starting dose | Target Dose |
|---|---|---|
| ACE-I | ||
| Captopril | 6.25 mg t.i.d. | 50 mg t.i.d. |
| Enalapril | 2.5 mg b.i.d. | 10–20 mg b.i.d. |
| Lisinopril | 2.5–5 mg o.d. | 20–35 mg o.d. |
| Ramipril | 2.5 mg b.i.d. | 5 mg b.i.d. |
| Trandolapril | 0.5 mg o.d. | 4 mg o.d. |
| ARNI | ||
| Sacubitril/valsartan | 49/51 mg b.i.d. | 97/103 mg b.i.d. |
| Beta-blockers | ||
| Bisoprolol | 1.25 mg o.d. | 10 mg o.d. |
| Carvedilol | 3.125 mg b.i.d. | 25 mg b.i.d. |
| Metoprolol succinate (CR/XL) | 12.5–25 mg o.d. | 200 mg o.d. |
| Nebivolold | 1.25 mg o.d. | 10 mg o.d. |
| MRA | ||
| Eplerenone | 25 mg o.d. | 50 mg o.d. |
| Spironolactone | 25 mg o.d.f | 50 mg o.d. |
| SGLT2 inhibitor | ||
| Dapagliflozin | 10 mg o.d. | 10 mg o.d. |
| Empagliflozin | 10 mg o.d. | 10 mg o.d. |
| Other agents | ||
| Candesartan | 4 mg o.d. | 32 mg o.d. |
| Losartan | 50 mg o.d. | 150 mg o.d. |
| Valsartan | 40 mg b.i.d. | 160 mg b.i.d. |
| Ivabradine | 5 mg b.i.d. | 7.5 mg b.i.d. |
| Vericiguat | 2.5 mg o.d. | 10 mg o.d. |
| Digoxin | 62.5 µg o.d. | 250 µg o.d. |
| Hydralazine/ Isosorbide dinitrate | 37.5 mg t.i.d./20 mg t.i.d. | 75 mg t.i.d./40 mg t.i.d. |