Necrotizing Skin and Soft Tissue Infection (NSSTI)

Specific Therapies to Know

Infection	Antimicrobial Regimen
Clostridium perfringens	penicillin + clindamycin
Vibrio vulnificus	ceftazidime + doxycycline
Aeromonas hydrophila	ciprofloxacin + doxycycline
Empiric NSSTI coverage	vancomycin/daptomycin/linezolid + pip-tazo; carbapenem; ceftriaxone + metronidazole; fluoroquinolone + metronidazole