Sjogren Syndrome

Management of Sjogren Syndrome

There is no disease-modifying treatment to reverse the manifestations of Sjogren syndrome.

Xerostomia and Sicca Symptoms

No medication alters the natural history of chronic oral and ocular dryness.

1. Nonpharmacologic therapies are first-line:
   1. Local moistening with water
   2. Sugar-free acidic candies and lozenges
   3. Sugar-free chewing gum (mechanical stimulants)
   4. Saliva substitutes
2. Medical therapies:
   1. cevilemine (muscarinic agonist) stimulates salivation
   2. pilocarpine (muscarinic agonist) is equally as effective